Oncogenic potential of Hsp72

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Oncogenic potential of EAG K(+) channels.

We have investigated the possible implication of the cell cycle-regulated K(+) channel ether à go-go (EAG) in cell proliferation and transformation. We show that transfection of EAG into mammalian cells confers a transformed phenotype. In addition, human EAG mRNA is detected in several somatic cancer cell lines, despite being preferentially expressed in brain among normal tissues. Inhibition of...

متن کامل

The Oncogenic Potential of Deregulated Homeobox Genes1

Homeobox genes encode DNA-binding proteins that regulate gene expression during embryonic development. Deregulation of homeobox gene expression has been invoked as the molecular basis of a number of leukemias. We now demonstrate, using in vitro and in vivo transformation assays, that the overexpression of homeobox genes is the basis for transformation and tumorigenesis. Thus, clustered homeobox...

متن کامل

Oncogenic Potential of Hepatitis C Virus Proteins

Chronic hepatitis C virus (HCV) infection is a major risk factor for liver disease progression, and may lead to cirrhosis and hepatocellular carcinoma (HCC). The HCV genome contains a single-stranded positive sense RNA with a cytoplasmic lifecycle. HCV proteins interact with many host-cell factors and are involved in a wide range of activities, including cell cycle regulation, transcriptional r...

متن کامل

Liver pro-oncogenic potential of SERPINB3

Hepatocellular Carcinoma (HCC) is a growing sanitary problem worldwide. This tumor is indeed the third most deadly and the fifth most common cancer all over the word, with an incidence that, at least in the United States, has doubled in the past two decades [1]. Current studies suggest that HCC can derive from liver progenitor cells or cancer stem cells (CSCs) in which signaling pathway similar...

متن کامل

Tyrosine kinase signaling in action potential shortening and expression of HSP72 in late preconditioning.

We investigated the role of tyrosine kinase (TK) signaling in the opening of the ATP-sensitive K(+) (K(ATP)) channel and 72-kDa heat shock protein (HSP72) expression during late preconditioning. Rabbits were subjected to surgical operation (sham) or were preconditioned (PC) with four cycles of 5 min of ischemia and 10 min of reperfusion. Twenty-four hours later, animals were subjected to 30 min...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Oncogene

سال: 1999

ISSN: 0950-9232,1476-5594

DOI: 10.1038/sj.onc.1202525